Integrated treadmill stress testing and MR relaxometry (T1, T2, T2*): response in healthy calf muscles
نویسندگان
چکیده
Background Peripheral arterial disease (PAD) is accompanied by a complex lower limb pathophysiology resulting in reduced functional capacity and quality of life. We aim to characterize the exercise recovery kinetics in the calf muscle of healthy volunteers by combining treadmill exercise and magnetic resonance (MR) relaxometry (T1, T2 and T2*), and to investigate their relation with age and treadmill exercise duration.
منابع مشابه
Exercise induced changes in T1, T2 relaxation times and blood flow in the lower extremities in healthy subjects
Background Current approaches to evaluate peripheral arterial disease (PAD) overwhelmingly rely on quantification of stenosis severity or flow across stenosis at rest. Although exerciseinduced functional alterations in metabolism have been proposed, there is a need to integrate approaches that provide additional risk measures in PAD that can be translated into clinical practice [1]. Recently, q...
متن کاملEvaluation of superparamagnetic iron oxide for MR imaging of liver injury: proton relaxation mechanisms and optimal MR imaging parameters.
PURPOSE To investigate the proton relaxation mechanisms and the optimal MR imaging parameters in superparamagnetic iron oxide (SPIO)-enhanced MR imaging of liver injury. METHODS A liver injury model was created in the rat using carbon tetrachloride. The T1 and T2 relaxation effects of SPIO in normal and injured liver were estimated by ex vivo relaxometry. In vivo laser confocal microscopy of ...
متن کاملin Vivo 35 cl Mr imaging in humans : A Feasibility Study 1
Materials and Methods: All examinations were performed with ethical review board approval; written informed consent was obtained from all volunteers. Seven examinations each of brain and muscle in healthy volunteers and four examinations of patients were performed. Two patients with histologically confirmed glioblastoma multiforme underwent brain imaging. 35Cl MR and 35Cl inversion-recovery (IR...
متن کاملStability and sensitivity of water T 2 obtained with IDEAL‐CPMG in healthy and fat‐infiltrated skeletal muscle
Quantifying muscle water T2 (T2 -water) independently of intramuscular fat content is essential in establishing T2 -water as an outcome measure for imminent new therapy trials in neuromuscular diseases. IDEAL-CPMG combines chemical shift fat-water separation with T2 relaxometry to obtain such a measure. Here we evaluate the reproducibility and B1 sensitivity of IDEAL-CPMG T2 -water and fat frac...
متن کاملHistogram-based characterization of healthy and ischemic brain tissues using multiparametric MR imaging including apparent diffusion coefficient maps and relaxometry.
Decreased, renormalized, or increased values of the calculated apparent diffusion coefficient (ADC) are observed in stroke models. A quantitative description of corresponding tissue states using ADC values may be extended to include true relaxation times. A histogram-based segmentation is well suited for characterizing tissues according to specific parameter combinations irrespective of the het...
متن کامل